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The activated signaling pathways promote the release of pro-inflammatory cytokines, leading to further aggravation of RA (227, 228)

The discrepancy in findings could stem from differences in experimental conditions: the former study used younger, developing animals fed on a lower-Fe diet (72 ppm), whereas the latter used mature adult mice fed a diet with nearly five-fold higher Fe content (350 ppm) (Shawki et al., 2015

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